Calculated Plasma Osmolality (CPO) Calculator
- Diagnosis of Electrolyte Imbalances: Identifies hypernatremia (high sodium) or hyponatremia (low sodium).
- Evaluation of Fluid Disorders: Helps detect dehydration, overhydration, and conditions like diabetes insipidus.
- Osmolal Gap Analysis: Detects toxic alcohol ingestion (e.g., methanol, ethylene glycol) when compared to measured osmolality.
- Quick Clinical Decision-Making: Offers rapid calculations to guide interventions in emergency and critical care settings.
Calculated Plasma Osmolality (CPO) Calculator
Where:
- \( [\text{Na}^+] \): Sodium concentration in mEq/L
- \( [\text{Glucose (mg/dL)}] \): Glucose concentration in mg/dL
- \( [\text{BUN (mg/dL)}] \): Blood Urea Nitrogen concentration in mg/dL
Description:
Calculated Plasma Osmolality (CPO) is an estimate of the osmolality of plasma, which is useful for evaluating electrolyte and fluid balance in patients, particularly in those with altered mental status, dehydration, or suspected intoxication.
Formula Explanation:
The formula involves multiplying the sodium concentration by 2, adding the glucose concentration (converted to molar units by dividing by 18), and adding the BUN concentration (converted to molar units by dividing by 2.8).
Normal Range:
The normal range for plasma osmolality is typically between 275 and 295 mOsm/kg.
-
Normal Values:
- Plasma osmolality typically ranges from 275 to 295 mOsm/kg.
- Values below 275 mOsm/kg indicate hypo-osmolality, while values above 295 mOsm/kg indicate hyperosmolality.
-
Peak Values:
- Plasma osmolality exceeding 320 mOsm/kg may indicate severe hypernatremia, hyperglycemia, or toxic ingestion, requiring urgent intervention.
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