Prader Staging Calculator

Where:

• Prader Staging is based on a score derived from clinical findings and hormonal tests in individuals with Prader-Willi Syndrome (PWS).

Description:

Prader Staging is used to classify the severity of Prader-Willi Syndrome (PWS), a genetic disorder characterized by hypotonia, feeding difficulties, developmental delay, and obesity. The stage of the syndrome is determined by clinical signs, symptoms, and hormonal findings.

Formula Explanation:

The Prader Staging system does not use a fixed mathematical formula but instead assigns a score based on the severity of clinical features and laboratory tests (such as growth hormone levels, insulin levels, and other endocrine abnormalities). The stages range from Stage I (mild) to Stage IV (severe).

Stages:

• Stage I (Mild): Minimal symptoms, normal development, no significant endocrine abnormalities.
• Stage II (Moderate): Mild to moderate developmental delay, some endocrine disturbances.
• Stage III (Severe): Significant developmental delay, moderate to severe endocrine disturbances (e.g., GH deficiency, hyperphagia).
• Stage IV (Very Severe): Severe developmental delay, marked endocrine abnormalities, and possible complications such as diabetes and obesity.

Usage:

The Prader Staging Calculator is helpful for healthcare providers in assessing the progression of Prader-Willi Syndrome and developing personalized treatment plans. It is important to note that this staging is based on clinical evaluation and patient history, and it may evolve over time.