Transtubular Potassium Gradient (TTKG) Calculator

Description Why Use

The Transtubular Potassium Gradient (TTKG) Calculator is a diagnostic tool used to assess the renal handling of potassium. It provides insight into the activity of aldosterone and the distal nephron's ability to concentrate potassium. TTKG is particularly useful in evaluating conditions like hyperkalemia, hypokalemia, and disorders of mineralocorticoid activity.

Why Use

  • Evaluate Potassium Imbalances: Helps determine the renal response to hypo- or hyperkalemia.
  • Assess Aldosterone Activity: Indicates whether aldosterone is appropriately regulating potassium secretion.
  • Guide Clinical Decisions: Assists in diagnosing and managing conditions like adrenal insufficiency, primary aldosteronism, and renal tubular disorders.
  • Monitor Therapy: Useful in tracking the efficacy of treatments targeting potassium balance.

Transtubular Potassium Gradient (TTKG) Calculator

TTKG Result:

TTKG = $$ \frac{[\text{Urinary K}^+ ] \times [\text{Plasma Osmolality}]}{[\text{Plasma K}^+ ] \times [\text{Urinary Osmolality}]} $$

Where:

  • \( [\text{Urinary K}^+] \): The concentration of potassium in urine (mEq/L)
  • \( [\text{Plasma Osmolality}] \): The osmolality of plasma (mOsm/kg)
  • \( [\text{Plasma K}^+] \): The concentration of potassium in plasma (mEq/L)
  • \( [\text{Urinary Osmolality}] \): The osmolality of urine (mOsm/kg)

Description:

The Transtubular Potassium Gradient (TTKG) is a measure used to evaluate how the kidneys handle potassium and to assess the renal response to potassium in the urine relative to its concentration in the blood. It is an important test in the diagnosis of potassium imbalances, helping to differentiate between renal and non-renal causes of hypo- or hyperkalemia.

Next Evidence Formula

TTKG is interpreted as follows:

  • <7: Suggests impaired renal potassium secretion (e.g., hypoaldosteronism, acute kidney injury).
  • >7: Indicates normal or excessive renal potassium secretion (e.g., hyperaldosteronism, diuretic use).

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